Coutinho strained his left hamstring during Barcelona's 1-1 draw with Internazionale in the Champions League on Tuesday.
The 26-year-old played the full 90 minutes but complained of discomfort after the match at the San Siro in Milan.
"Tests undertaken on Thursday morning have confirmed that Philippe Coutinho has a small rupture in the femoral biceps of his left leg," Barcelona said on their official website on Thursday. Also Read: Chelsea legend Didier Drogba to visit India "He will be out for approximately two to three weeks."
The injury rules Coutinho out of Barcelona's La Liga clash with Real Betis at the Camp Nou on Sunday and is also expected to keep him out of Brazil's friendlies against Uruguay and Cameroon later this month.